Logical modelling and analysis of the budding yeast cell cycle
نویسندگان
چکیده
منابع مشابه
Modular logical modelling of the budding yeast cell cycle.
Systems biologists are facing the difficult challenge of modelling and analysing regulatory networks encompassing numerous and diverse components and interactions. Furthermore, available data sets are often qualitative, which complicates the definition of truly quantitative models. In order to build comprehensive and predictive models, there is clearly a need for incremental strategies, enablin...
متن کاملLogical analysis of the budding yeast cell cycle.
The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to investigate control of the eukaryotic cell cycle. Moreover, because of the extensive experimental data on wild type and mutant phenotypes, it is also particularly suitable for mathematical modelling and analysis. Here, I present a new Boolean model of the budding yeast cell cycle. This model is consistent wi...
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Budding yeast Saccharomyces cerevisiae is a standard model system for analyzing cellular response as it is related to the cell cycle. The analysis of yeast cell cycle is typically done visually or by using flow cytometry. The first of these methods is slow, while the second offers a limited amount of information about the cell's state. This thesis develops methods for automatically analyzing ye...
متن کاملIntegrative analysis of cell cycle control in budding yeast.
The adaptive responses of a living cell to internal and external signals are controlled by networks of proteins whose interactions are so complex that the functional integration of the network cannot be comprehended by intuitive reasoning alone. Mathematical modeling, based on biochemical rate equations, provides a rigorous and reliable tool for unraveling the complexities of molecular regulato...
متن کاملStochastic Modeling of Budding Yeast Cell Cycle
This report presents the definition, solution and validation of a stochastic model of the budding yeast cell cycle, based on Stochastic Petri Nets. A well-established deterministic model, based on ODEs, is considered as the basis for the stochastic modeling. A specific class of Stochastic Petri Nets is selected for building a stochastic version of the deterministic model, with applying the same...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2007
ISSN: 1471-2105
DOI: 10.1186/1471-2105-8-s8-p1